| Egb761对大鼠海马神经细胞缺血再灌注损伤保护作用的形态学研究 |
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| 引用本文： | 闵珉,姚晨玲.Egb761对大鼠海马神经细胞缺血再灌注损伤保护作用的形态学研究[J].中国临床医学,2009,16(5):686-688. |
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| 作者姓名： | 闵珉 姚晨玲 |
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| 作者单位： | 复旦大学附属中山医院急诊科,上海,200032 |
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| 基金项目： | 上海市科委资助项目(034119902) |
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| 摘 要： | 目的：从形态学探讨Egb761对大鼠海马神经细胞缺血再灌注损伤保护作用。方法：用四血管法建立大鼠全脑缺血再灌注模型。24只大鼠随机分为3组（分别为假手术组,缺血再灌注组和Egb761治疗组）。观察海马神经元缺血再灌注后HE染色、TUNEL染色及透射电子显微镜下改变。结果：海马神经原水肿、凋亡等改变在缺血再灌注组明显高于假手术组,Egb761组介于上述两组之间。结论：缺血再灌注后神经细胞发生水肿、凋亡、坏死等形态学改变,Egb761对大鼠海马神经细胞缺血再灌注损伤具有保护作用。
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| 关 键 词： | Egb761 海马 凋亡 形态学 |
Morphological Investigation of the Neuroprotective Effect of Ginkgo Biloba Extract (Egb761) on Hippocampal Neuronal Cell in Ischemia-reperfusion Injured Rats |
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| MIN Min,YAO Chenling.Morphological Investigation of the Neuroprotective Effect of Ginkgo Biloba Extract (Egb761) on Hippocampal Neuronal Cell in Ischemia-reperfusion Injured Rats[J].Chinese Journal Of Clinical Medicine,2009,16(5):686-688. |
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| Authors: | MIN Min YAO Chenling |
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| Institution: | MIN Min YAO Chenling Department of Emergency,Zhongshan Hospital,Fudan University,Shanghai 200032,China |
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| Abstract: | Objective:To investigate the neuroprotective effect of Egb761 on morphology of hippocampal neuronal cell in ischemia-reperfusion injured rats.Methods:The ischemia-reperfusion model was established by the occlusion of the 4 vessels. 24 rats were randomly divided into 3 groups (control group,ischemia-reperfusion group and EGb761 treatment group). Morphological changes of hippocampal neuronal cell were observed by hematoxylin-eosin staining,the terminal deoxynucleotidyl transferase-mediated deoxyuridine tripho... |
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| Keywords: | Ginkgo biloba extract Hippocampus Apoptosis Morphology |
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