N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein,microtubule organization,and telomeric DNA期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein,microtubule organization,and telomeric DNA

Authors:	Aruna?S?Jaiswal,Asha?S?Multani,Sen?Pathak,Satya?Narayan author-information" > author-information__contact u-icon-before" > mailto:snarayan@ufscc.ufl.edu" title=" snarayan@ufscc.ufl.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) UF Shands Cancer Center and Anatomy and Cell Biology, College of Medicine, Academic Research Building, Room R4-216, University of Florida, PO Box 100232, Gainesville, FL 32610, USA;(2) Department of Molecular Genetics, unit & 011, The University, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA

Abstract:	Background Cellular senescence is a state in which mammalian cells enter into an irreversible growth arrest and altered biological functions. The senescence response in mammalian cells can be elicited by DNA-damaging agents. In the present study we report that the DNA-damaging agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is able to induce senescence in the HCT-116 colon cancer cell line.

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