肝移植后肝动脉血栓形成的危险因素及防治措施

目的探讨肝移植后肝动脉血栓形成的好发因素及其防治措施。方法收集国内、外近年来关于肝移植后肝动脉血栓形成的好发因素及防治方面的文献并作一综述。结果肝移植后肝动脉血栓形成的好发因素有第五因子莱顿、受体的代谢性肝脏疾病和受体的性别、肝移植中Roux-en-Y法胆管重建术的应用、病毒感染等方面;防治措施主要有早期诊断、检测激活蛋白C抵抗性与预防性应用抗凝剂、改进肝动脉重建的方法、高压氧疗法、经导管持续溶栓治疗、再次肝移植等方面。结论肝移植后肝动脉血栓形成的好发因素及其防治措施的研究对改善肝移植患者的预后有指导作用。

Risk Factors, Prevention and Therapy of Hepatic Artery Thrombosis after Liver Transplantation

Objective To investigate the risk factors, prevention and therapy of hepatic artery thrombosis after liver transplantation. Methods The literatures on the risk factors, prevention and therapy of hepatic artery thrombosis after liver transplantation in recent years were collected and reviewed. Results The risk factors include factor V Leiden, metabolic liver diseases of recipients, recipient sex, the use of Roux-en-Y biliary reconstructions, virus infection and so on. The measures of prevention and therapy include early diagnosis, detection of activated protein C resistance, postoperative anti-coagulation therapy, liver arteries reconstructions measures, hyperbaric oxygen therapy, continuous transcatheter arterial thrombolysis, liver retransplantation and so on. Conclusion The study of risk factors, prevention and therapy will promote the process of improving the prognosis of patients with liver transplantation.