Correlation and Agreement of Yttrium-90 Positron Emission Tomography/Computed Tomography with Ex Vivo Radioembolization Microsphere Deposition in the Rabbit VX2 Liver Tumor Model期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Correlation and Agreement of Yttrium-90 Positron Emission Tomography/Computed Tomography with Ex Vivo Radioembolization Microsphere Deposition in the Rabbit VX2 Liver Tumor Model

Authors:	Andrew C Gordon Vanessa L Gates Sarah B White Kathleen R Harris Daniel Procissi Zhuoli Zhang Weiguo Li Donald Samaan Jodi R Nicolai Samdeep K Mouli Kent T Sato Robert K Ryu Reed A Omary Riad Salem Robert J Lewandowski Andrew C Larson

Institution:	1. Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois;2. Department of Medicine, Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois;3. Department of Surgery, Organ Transplantation, Northwestern University, Feinberg School of Medicine, Chicago, Illinois;4. Department of Biomedical Engineering, Northwestern University, Evanston, Illinois;5. Department of Radiology, Division of Vascular & Interventional Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin;6. Medical Health Physics, Stanford University, Palo Alto, California;7. Department of Radiology, University of Colorado, Aurora, Colorado;8. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee

Abstract:	PurposeTo demonstrate a stronger correlation and agreement of yttrium-90 (⁹⁰Y) positron emission tomography (PET)/computed tomography (CT) measurements with explant liver tumor dosing compared with the standard model (SM) for radioembolization.Materials and MethodsHepatic VX2 tumors were implanted into New Zealand white rabbits, with growth confirmed by 7 T magnetic resonance imaging. Seventeen VX2 rabbits provided 33 analyzed tumors. Treatment volumes were calculated from manually drawn volumes of interest (VOI) with three-dimensional surface renderings. Radioembolization was performed with glass ⁹⁰Y microspheres. PET/CT imaging was completed with scatter and attenuation correction. Three-dimensional ellipsoid VOI were drawn to encompass tumors on fused images. Tumors and livers were then explanted for inductively coupled plasma (ICP)-optical emission spectroscopy (OES) analysis of microsphere content. ⁹⁰Y PET/CT and SM measurements were compared with reference standard ICP-OES measurements of tumor dosing with Pearson correlation and Bland-Altman analyses for agreement testing with and without adjustment for tumor necrosis.ResultsThe median infused activity was 33.3 MBq (range, 5.9–152.9). Tumor dose was significantly correlated with ⁹⁰Y PET/CT measurements (r = 0.903, P < .001) and SM estimates (r = 0.607, P < .001). Bland-Altman analyses showed that the SM tended to underestimate the tumor dosing by a mean of ?8.5 Gy (CI, ?26.3–9.3), and the degree of underestimation increased to a mean of ?18.3 Gy (CI, ?38.5–1.9) after the adjustment for tumor necrosis.Conclusions⁹⁰Y PET/CT estimates were strongly correlated and had better agreement with reference measurements of tumor dosing than SM estimates.

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