Use of Intravenous Thrombolysis in Acute Ischemic Stroke Management in Patients with Active Malignancies: A Topical Review |
| |
| Authors: | Asma Akbar Ladak Sonia Sandhu Ahmed Itrat |
| |
| Affiliation: | 2. Cleveland Clinic Akron General, Akron, Ohio, USA;3. Cerebrovascular Center, Cleveland Clinic, Cleveland, Ohio, USA;2. Department of Neurosurgery, All India Institute of Medical Sciences, Bhopal, India;3. Department of Neurosurgery, University of Cartagena, Cartagena de Indias, Colombia;2. Komfo Anokye Teaching Hospital, Kumasi, Ghana;3. Department of Neurology, University of California, San Francisco, USA;2. Department of Medical Education, University of Melbourne and Eastern Health, Australia;3. Hypertension Research Centre, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;4. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Gland Surgery, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China;3. Department of Radiology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, Hebei Province 050000, China;2. Division of Occupational Therapy, Yamagata City Hospital Saiseikan, 1-3-26 Nanukamachi, Yamagata 990-8533, Japan;3. Graduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, 260 Kamiyanagi, Yamagata 990-2212, Japan;2. Department of Quality and Patient Safety, University of California San Diego Health, San Diego, CA 619-543-1982 USA |
| |
| Abstract: | ObjectivesOur review aims to present existing data on the safety of Intravenous thrombolysis (IVT) use in acute ischemic stroke (AIS) patients with concomitant central nervous system or systemic malignancies, with attention to special circumstances pertaining to specific cancer subtypes to help in acute decision making, especially for neurologists and emergency medicine physicians.MethodsA literature search was conducted on electronic databases inclusive of Medline, EMBASE and CINAHL for articles published or available in English between January 1, 2000 to June 1, 2020 using the following search terms: “acute ischemic stroke,” “cerebrovascular disease,” “Intravenous thrombolysis,” “tissue plasminogen activator,” “cancer patients,” and “neoplasm”.ConclusionRecognition of stroke symptoms in patients with active cancer, in particularly those involving the brain, requires astute clinical judgement. Decision-making can be improved by understanding baseline functional status, cancer prognosis and expected disability from stroke, as well as utilizing diagnostic modalities such acute MRI where needed. While this article does not encourage use of IVT in patients with all malignancies, it lays the groundwork for decision making should thrombolysis be a consideration in a patient with AIS in a cancer patient. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
