Ferumoxtran-10-enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with non-Hodgkin lymphomas |
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Authors: | Stephan Metz Stefanie Lohr Marcus Settles Ambros Beer Klaus Woertler Ernst J Rummeny Heike E Daldrup‒Link |
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Institution: | (1) Department of Diagnostic Radiology, Technische Universitaet Muenchen, Ismaninger Str. 22, 81675 Munich, Germany;(2) Department of Radiology, University of California, San Francisco, USA |
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Abstract: | To quantify permeability changes of the “blood–bone marrow barrier” (BMB) and to detect malignant bone marrow infiltrations
before and after conditioning therapy for subsequent leukapheresis using ferumoxtran-10-enhanced magnetic resonance (MR) imaging.
Twenty-two patients with malignant non-Hodgkin lymphomas (NHL), including 9 patients (group A) before and 13 patients (group
B) after conditioning therapy, underwent MR of the spine before and after infusion of ferumoxtran-10 (0.045 mmol Fe/kg BW).
Pulse sequences comprised dynamic T1-GE and pre- and post-contrast T1-SE and STIR sequences. Dynamic ΔSI-data were correlated
with the quantity of mobilized CD34+ cells. In addition, the number of focal bone marrow lesions was compared before and after
ferumoxtran-10 administration. Dynamic ΔSI-data were higher in group B than in group A, indicating an increased BMB permeability
after conditioning therapy. However, ΔSI-data did not correlate with the quantity of mobilized CD34+ cells. Ferumoxtran-10-enhanced
STIR images demonstrated a significant signal decline of the normal, non-neoplastic bone marrow and a significantly increased
detection of focal neoplastic lesions compared to pre-contrast images (P<0.05). Ferumoxtran-10 depicted the bone marrow response to conditioning therapy by an increase in BMB-permeability, which,
however, did not correlate with the number of mobilized CD34+ cells. Ferumoxtran-10 improved the detection of focal bone marrow
lesions significantly (P<0.05). |
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Keywords: | Blood-bone marrow barrier Ferumoxtran-10 MR |
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