Effect of the immunomodulant ximedone on the pharmacokinetics of isonicotinic acid hydrazide in the human organism |
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| Authors: | S. Yu. Garmonov V. I. Pogorel’tsev N. S. Shitova T. A. Kiseleva E. V. Degterev M. I. Evgen’ev |
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| Affiliation: | (1) Kazan State Technological University, Kazan, Tatarstan, Russia;(2) Kazan State Medical University Kazan, Tatarstan, Russia;(3) Center for Drug Chemistry-All-Russia Research Institute of Pharmaceutical Chemistry, Moscow, Russia |
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| Abstract: | The pharmacokinetics of isonicotinic acid hydrazide upon joint administration with the immunomodulant ximedone has been investigated. Ximedone influences the genetically determined parameters of the isonicotinic acid hydrazide pharmacokinetics. The dose-dependent and temporal schedules of ximedone administration in humans are established, which favor the induction of acetylation processes in patients. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 3–6, March, 2006. |
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