Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate |
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| Authors: | Jürgen Homann Sabine Schneider Karl-John Matthes |
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| Affiliation: | (1) Department of Internal Medicine, Justus-Liebig-University Gießen, Klinikstr. 36, D-6300 Gießen, Federal Republic of Germany;(2) Institute of Clinical Chemistry and Biochemistry, Justus-Liebig-University Gießen, Klinikstr. 36, D-6300 Gießen, Federal Republic of Germany |
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| Abstract: | Intoxication of male rats with 5 mg/kg parathion reduces survival to 15%. Diethyldithiocarbamate (DDC), known to inhibit mixed-function oxidase activity, has no effect on survival rate when this compound is used in a dosage of 300 mg/kg 45 min before or 10 min after parathion intoxication. However, when DDC and parathion are administered simultaneously, the rate of survival rises to 53%. |
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| Keywords: | Rats Parathion Diethyldithiocarbamate Mixed-function oxidase |
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