| 用超临界流体色谱法测定怀牛膝及其制剂中齐墩果酸的含量 |
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| 引用本文： | 吴玫涵,李修禄,王梅,刘锦耀,张美义. 用超临界流体色谱法测定怀牛膝及其制剂中齐墩果酸的含量[J]. 药学学报, 1992, 27(9): 690-694 |
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| 作者姓名： | 吴玫涵 李修禄 王梅 刘锦耀 张美义 |
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| 作者单位： | 第二军医大学药学院,上海200433;*北京丰台西路17号总后药检所生化室,100071;**云南省分析测试中心,昆明650011;***成都军区昆明总医院,昆明650032 |
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| 摘 要： | 采用超临界流体色谱法(SFC)分别测定了不同产地的怀牛膝药材及三种含怀牛膝的制剂中齐墩果酸的含量。方法简单、快速。不需经特殊的纯化处理。各产地药材齐墩果酸含量波动较小(1.75～2.19%,x±SD=1.94±0.17%),可以作为药材与制剂质量评价的指标,药材的加样回收率为97.42%(n=18,RSD=2.80%);制剂天麻丸的加样回收率为94.82%(n=9,RSD=2.51%)。
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| 关 键 词： | 超临界流体色谱法 怀牛膝 齐墩果酸 天麻丸 金匮肾气丸 河车大造丸 |
| 收稿时间： | 1990-07-24 |
DETERMINATION OF OLEANOLIC ACID IN ACHYRANTHES BIDENTATA BLUME AND ITS PREPARATIONS BY SUPERCRITICAL FLUID CHROMATOGRAPHY |
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| MH Wu,XL Li,M Wang,JY Liu,MY Zhang. DETERMINATION OF OLEANOLIC ACID IN ACHYRANTHES BIDENTATA BLUME AND ITS PREPARATIONS BY SUPERCRITICAL FLUID CHROMATOGRAPHY[J]. Acta pharmaceutica Sinica, 1992, 27(9): 690-694 |
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| Authors: | MH Wu XL Li M Wang JY Liu MY Zhang |
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| Affiliation: | School of Pharmacy, Second Military Medical University, Shanghai. |
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| Abstract: | Capillary SFC was used for the determination of oleanolic acid in Achyranthes bidentata BLume and its preparations Tianmawan, Jinguishenqiwan and Hechedazaowan. The amount of oleanolic acid in the root of Achyranthes bidentata BLume was 1.75-2.19% (mean +/- SD = 1.94 +/- 0.17%). The limit of detection was 9.605 x 10(-11) g. The method is highly sensitive, accurate, reproducible, simple, rapid and specific, so, it can be extensively used for the determination of other preparations and crude herbs. |
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| Keywords: | Achyranthes bidentata BL. Oleanolic acid Supercritical fluid chromatography |
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