非增殖型糖尿病视网膜病变治疗的临床证据

目的对非增殖型糖尿病视网膜病变(nonproliferative diabeticretinopathy,NPDR)治疗的临床相关研究证据进行评价。方法检索Cochrane图书馆(2007年第3期)、PubMed(1966~2007.6)、CBM(1979~2007.6)等数据库中与NPDR有关的临床研究证据,并对所获证据质量进行评价。结果共纳入1篇系统评价,20个随机对照试验。临床证据显示,严格控制血糖和血压是治疗NPDR的基本方法,可延缓患者视网膜病变进展。其它治疗措施的价值尚需进一步研究。结论NPDR是糖尿病视网膜病变的早期阶段,相关的系统评价和高质量的随机对照研究证实控制血糖和血压在治疗NPDR中的作用。其它治疗措施的价值有待相关的系统评价和更多大样本、多中心的高质量临床研究证实。

Clinical Evidence on the Treatment of Non-proliferative Diabetic Retinopathy

Objective To summarize the available clinical evidence on the treatment of non-proliferative diabetic retinopathy (NPDR). Methods Based on the basic methods and principles of evidence-based medicine, we searched and evaluated the NPDR-related evidence from the Cochrane Library(Issue 3,2007), PubMed (1966 to June 2007) and CBM(1979 to June 2007) Results We finally identified 1 systematic review and 20 randomized controlled trials. Clinical evidence showed that critical glycemic control and blood pressure control were essential in the treatment of NPDR, whichmight delay the progression of retinopathy. The e ectiveness of other therapeutic measures needed to be further investigated. Conclusion NPDR is the early stage of diabetic retinopathy (DR). Relevant systematic reviews and high-quality randomized controlled trials have confirmed the effectiveness of critical control of blood glucose and blood pressure for NPDR. The e ectiveness of other therapeutic measures needs to be con rmed by systematic reviews of high quality and rigorously designed randomized, multi-center and large-scale trials.