Bone Marrow Metastasis in Ewing's Sarcoma and Peripheral Primitive Neuroectodermal Tumor: An Immunohistochemical Study |
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Authors: | EJ Lazda PJ Berry |
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Institution: | (1) Department of Paediatric Pathology, St. Michael's Hospital, Southwell Street, Bristol BS2 8EG, UK , GB |
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Abstract: | Bone marrow metastases from small round cell tumors can present diagnostic difficulties. In this study, we assessed the value
of immunohistochemistry, using two monoclonal antibodies to CD99, for the diagnosis of metastatic disease in bone marrow trephine
specimens from patients with Ewing's sarcoma or primitive neuroectodermal tumor (PNET). The proportions of specimens showing
metastases were 10.3% with routine staining and 20.7% with immunohistochemistry. The specimens that were negative on conventional
light microscopy and positive with immunohistochemistry all showed other abnormalities. The results do not support the routine
use of immunohistochemistry in specimens that are normal by conventional light microscopy, but indicate that useful information
may be gained in cases where marrow histology is obscured by fibrosis, necrosis, or distortion artefact. Neither of the two
antibodies tested was superior for this purpose.
Received January 17, 1997; accepted May 22, 1997 |
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Keywords: | : bone marrow metastasis Ewing's sarcoma immunohistochemistry CD99 peripheral neuroectodermal tumor |
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