ICU重症患者CRBSI临床相关危险因素研究

目的探讨ICU内中心静脉导管（CVC）相关血行感染（CRBSI）的发生率和临床相关危险因素。方法对ICU内拟诊和确诊CRBSI患者9年的临床资料进行回顾性分析,将ICU内中心静脉置管情况和CRBSI年度发生率,以及患者基础疾病、住ICU时间、CVC留置时间等相关危险因素等进行研究。结果 ICU重症患者中心静脉置管率为40.97%,CRBSI的发病率为4.32%,病死率24.4%。CRBSI患者的基础疾病、住ICU时间、CVC留置时间、静脉营养为CRBSI的相关危险因素（P〈0.05）。ICU内CRBSI发生率为4.32%。结论随着患者危重病程度增加、住ICU时间和留置导管时间延长,CRBSI的发生几率显著增加。

Clinical study of CRBSI and their related risk factors in critically ill patients

Objective To study the incidence of central venous catheter-related bloodstream infection（CRBSI） and related risk factors in critically ill patients.Methods The clinical data of all patients who were preliminarily and definitely diagnosed of CRBSI period nine years（2000-2008） in ICU were collected and studied retrospectively.And the annual incidence of CRBSI was analyzed.Basic disease,duration of in ICU,period and location of CVC,nutrition implement,surgery and mechanical ventilation of patients were made by regression analysis.Results The rate of central venous catheterization was 40.97% in critically ill patients in ICU and the incidence of CRBSI was 4.32%.The mortality rate of CRBSI was 24.4%.Basic disease,period of CVC,length of stay（LOS） in ICU and potential nutrition of patients were related risk factors of CRBSI（P0.05）.Conclusion The infection rate of CRBSI is 4.32% in ICU.With APACHEII increasing,LOS in ICU and the remaining time of CVC are prolonged,the incidence rate of CRBSI increased.