左卡尼汀对体外循环心脏手术患者心肌的保护作用

目的：研究左卡尼汀对体外循环心脏手术患者心肌的保护作用。方法：以接受体外循环手术患者40例，随机分为治疗组（20例）、对照组（20例）。分别对所有患者术前，转流毕，术后8h、术后24h抽取静脉血用全自动生化分析仪监测肌酸激酶（CK）、肌酸激酶同工酶（CKMB）；术前1d和术后7d行心脏彩超了解患者心脏指数（CI）、左心射血分数（LVEF）；心脏自动复跳率观察；记录患者术毕心脏自动复跳率血管活性药物的用量比较。结果：1．两组患者血清CK、CK—MB水平与手术前比较无显著性差异，两组血清CK水平在升主动脉开放后显著升高，于术后24h达高峰，其中治疗组升高水平在8h、24h较对照组低（P〈0．05）。2．术后7d，治疗组CI、LVEF明显高于对照组（P〈0．05）．3．治疗组患者转流毕和术后血管活性药物的用量明显少于对照组（P〈0．01）．4．治疗组患者转流毕心脏自动复跳率（85％）明显高于对照组（60％）。结论：左卡尼汀在体外循环中对心肌细胞起到了保护作用。

Protective Effects of Lcarnitine on Myocardium Function in Patients Undergoing Cardiopulmonary Bypass

Objective To investigate the effect of Lcarnitine on myocardial enzymes in patients with Congenital Heart Disease(CHD) undergoing open cardiac operation with cardio pulmonary bypass(CPB).Methods 40 patients with CHD were randomly divided into two groups as test group and control group(n=20 in each group).Lcarnitine was put in the cold ST.Thomas E crystal cardiac arresting liquid in the test group,other experimental conditions were same between two groups.Before operation,ending of the aortic clamping and at...