| 自体CIK细胞及DC细胞联合索拉非尼治疗晚期肝癌的临床观察 |
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| 引用本文： | 李建旺,彭大为,黄春珍,元建华. 自体CIK细胞及DC细胞联合索拉非尼治疗晚期肝癌的临床观察[J]. 实用癌症杂志, 2011, 26(5): 459-461 |
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| 作者姓名： | 李建旺 彭大为 黄春珍 元建华 |
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| 作者单位： | 海口市人民医院(中南大学湘雅医学院附属海口医院)肿瘤科,570208 |
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| 摘 要： | 目的观察晚期肝癌患者行自体CIK细胞及树突状细胞联合索拉非尼治疗的临床疗效及不良反应。方法采用患者自体外周血进行细胞因子诱导的杀伤细胞（cytokine induced killer,CIK）及树突状细胞（dendritic cell,DC）扩增,并应用流式细胞术检测其CIK、DC-CIK表型,然后采取静脉回输方法,对原发性肝癌进行自体的CIK细胞及DC细胞联合索拉非尼治疗。结果索拉非尼联合1个疗程DC-CIK治疗后CR 0例,PR 15例,MR 22例,SD 5例,PD 2例,总缓解（CR＋PR＋MR）率为84.1%。患者免疫功能提高,生活质量改善。结论自体CIK细胞及树突状细胞联合索拉非尼治疗晚期肝癌患者疗效尚可,不良反应可耐受。
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| 关 键 词： | 晚期肝癌 索拉非尼 CIK细胞 DC细胞 过继免疫疗法 |
Autologous CIK and DC Combined with Sorafenib in The Treatment of Patients with Advanced Hepatocellular Carcinoma: A Clinical Observation |
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| LI Jiang-wang,PENG Da-wei,HUANG Chun-zheng,et al.. Autologous CIK and DC Combined with Sorafenib in The Treatment of Patients with Advanced Hepatocellular Carcinoma: A Clinical Observation[J]. The Practical Journal of Cancer, 2011, 26(5): 459-461 |
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| Authors: | LI Jiang-wang PENG Da-wei HUANG Chun-zheng et al. |
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| Affiliation: | LI Jiang-wang,PENG Da-wei,HUANG Chun-zheng,et al.Department of Oncology,People's Hospital of Haikou(Xiangya Haikou Hospital of Central-south University),Haikou,570208 |
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| Abstract: | Objective To analyze the clinical efficacy and side effects in patients with advanced hepatic cancer treated with Sorafenib and autologous CIK and CD.Methods Cytokine-induced killer cells(cytokine induced killer,CIK) and dendritic cells(Dendritic Cell,DC) from the peripheral blood of the patients with advanced hepatocellular carcinoma were amplified.The amplified CIK and DC-CIK were transfused back,and Sorafenib was given to the patients,after the phenotype of CIK and DC-CIK was tested by using the flow cyt... |
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| Keywords: | Advanced hepatocellular carcinoma Sorafeni CIK cells DC cells Adoptive immunotherapy |
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