序贯法测定丙泊酚意识消失的半数有效量探讨

目的测定丙泊酚意识消失的半数有效量（ED50）和意识消失的全量,并探讨其与剂量关系。方法将48例患者分为两组（n=24）,采用序贯给药法测定丙泊酚意识消失的ED50,意识消失全量的测定是以20mg/（kg.h）速度泵入丙泊酚直至患者眼睑反射消失,和对呼喊没有反应（意识消失指标）时停止泵药,记录泵入时间并计算丙泊酚用量。结果丙泊酚意识消失的ED50和全量分别是1.018mg/kg（95%CI,0.785-1.320 mg/kg）和（1.856±0.265）mg/kg。结论丙泊酚意识消失的ED50值为1.018mg/kg,意识消失的全量约为1.8 ED50。

Determination of the median effective dose of propofol for loss of consciousness by sequential experimental method

Objective To determine the dose of propofol at which 50% and 100% of patients fall into unconsciousness,and explore the relation between them.Methods 48patients were randomly divided equally into two groups（n=24）,50% of patients of loss of consciousness（LOC） for propofol were studied by sequential experimental method,and 100% of patients of LOC for propofol were studied by the method which propofol were continuously pumped through vein at the speed of 20mg/（kg·h） until the patients loss of responses to eyelash stimulation and verbal command.Results The median effective dose（ED50） and 100% effective dose of propofol for LOC（95% CI） were respectively 1.018（0.785-1.320） mg/kg and（1.856±0.265）mg/kg.Conclusion The ED50 of propofol for LOC is 1.018 mg/kg,and the 100% effective dose of propofol for LOC is 1.8 ED50.