| p-p38和VEGF在原发性肝癌中的表达及相关性研究 |
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| 引用本文： | 魏小勇,饶荣生. p-p38和VEGF在原发性肝癌中的表达及相关性研究[J]. 江西医药, 2009, 44(2): 107-109 |
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| 作者姓名： | 魏小勇 饶荣生 |
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| 作者单位： | 南昌大学医学院,南昌,330006;江西省肿瘤医院,南昌,330029 |
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| 摘 要： | 目的研究磷酸化p38（p-p38）和血管内皮生长因子（VEGF）在原发性肝癌中的表达及与临床病理特衙的关系。方法采用免疫组织化学S-P法，检测53例原发性肝癌组织，30例非癌肝组织中的p—p38和VEGF表达情况并分析其相关性及临床病理特征．结果p—p38和VEGF阳性表达率在原发性肝癌组织明显高于非癌肝组织，与患者年龄、性别、病理分型、肿块最大径等临床病理特征参数没有相关性。但与肝癌的转移、癌栓、组织分化程度有相关性，p—p38和VEGF在肝癌中的表达呈正相关r=0．458（P=0．001，P〈0．05）。结诊p-p38和VFCF讨表认存肝痛的发展及浔润转移中具有首要作用.
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| 关 键 词： | 原发性肝癌 P-p38 VEGF 免疫组织化学 |
Correlation between expression of p-p38 and VEGF in primary hepatocellular carcinoma |
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| WEI Xiaoyong,RAO Rongsheng. Correlation between expression of p-p38 and VEGF in primary hepatocellular carcinoma[J]. Jiangxi Medical Journal, 2009, 44(2): 107-109 |
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| Authors: | WEI Xiaoyong RAO Rongsheng |
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| Affiliation: | WEI Xiaoy-ong,RAO Rongsheng.The Medical College of Nanchang University,Nanchang,330006,China |
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| Abstract: | objective To investigate the expression of phosphorylated p38MAPK(p-p38) and Vascular endothelial growth factor(VEGF) in primary hepatocellular carcinoma,and study on correlation between p-p38,VEGF and clinicopathologic features.Methods Using S-P immunohistochemical method to detect the expression of p-p38 and VEGF in 53 hepatocellular carcinoma tissues,30 paracancerous tissues.Results The positive rates of p-p38 and VEGF in the tissues of hepatocellular carcinoma were significantly higher than those in par... |
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| Keywords: | P-p38 VEGF |
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