Biooxidation of 7,12-dimethylbenz[a]anthracene in rat subcutaneous tissue |
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| Authors: | S R Myers J W Flesher |
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| Affiliation: | Department of Pharmacology, Albert B. Chandler Medical Center, University of Kentucky College of Medicine, Lexington 40536. |
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| Abstract: | The present study demonstrates the biooxidation of 7,12-dimethylbenz[a]anthracene to the corresponding hydroxyalkyl metabolites, 7-hydroxymethylbenz[a]anthracene, 7-hydroxymethyl-12-methylbenz[a]anthracene, and 7,12-dihydroxymethylbenz[a]anthracene in the dorsal subcutaneous tissue of the rat, in vivo, a tissue highly susceptible to the carcinogenic action of 7,12-dimethylbenz[a]anthracene. |
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