Development and characterization of a scalable microperforated device capable of long-term zero order drug release |
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| Authors: | Ashish Rastogi Zhiquan Luo Zhuojie Wu Paul S Ho Phillip D Bowman Salomon Stavchansky |
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| Institution: | (1) Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA;(2) Microelectronics Research Center, MER/MRC, The University of Texas at Austin, Austin, TX 78758, USA;(3) U.S. Army Institute of Surgical Research, San Antonio, TX 78234, USA; |
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| Abstract: | A drug delivery system that consists of microperforated polyimide microtubes was developed and characterized. Two groups of
polyimide tubes were used. One set consisted of microtubes (I.D. = 125 μm) with 32.9 ± 1.7 μm size holes. The second set consisted
of larger tubes (I.D. = 1000 μm) with 362–542 μm holes. The number of holes was varied between 1 and 3. The small tubes were
loaded with crystal violet (CV) and ethinyl estradiol (EE) and the drug release studies were performed in 0.01 M phosphate
buffered saline (PBS) (pH 7.1–7.4) at 37.0 ± 1.0°C for upto 4 weeks. The large tubes were loaded with CV and the drug release
was studied in vitro in PBS and also ex vivo in rabbit’s vitreous humor. Linear release rates with R2 > 0.9900 were obtained for all groups with CV and EE. Release rates of 7.8 ± 2.5, 16.2 ± 5.5, and 22.5 ± 6.0 ng/day for CV
and 30.1 ± 5.8 ng/day for EE were obtained for small tubes. For large tubes, a release rate of 10.8 ± 4.1, 15.8 ± 4.8 and
22.1 ± 6.7 μg/day was observed in vitro in PBS and a release rate of 5.8 ± 1.8 μg/day was observed ex vivo in vitreous humor. |
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