SOS induction in Escherichia coli and Salmonella mutagenicity: a comparison using 330 compounds |
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| Authors: | Mersch-Sundermann Volker; Schneider Uli; Klopman Gilles; Rosenkranz Herbert S |
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| Institution: | Department of Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg FRG
1Chemistry Department, Millis Science Center, Case Western Reserve University Cleveland, OH 44106, USA
2Center for Environmental and Occupational Health and Toxicology, University of Pittsburgh RIDC Park, Pittsburgh, PA 15261, USA |
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| Abstract: | To examine the concordance of two microbial genotoxicity short-termassays, 330 experimental results for the SOS chromotest usingtester strain Escherichia coli PQ37 were compared with the resultsof the Salmonella/mammalian microsome mutagenicity assay withSalmonella typhimurium TA97, TA98, TA100, TA102, TA104, TA1535,TA1537 and/or TA1538. With respect to qualitative features,the concordance between SOS chromotest and Salmonella mutagenicitytest results was 86.4% (sensitivity, 78.6%; specificity, 100%; |
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