| 阿立哌唑的合成 |
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| 引用本文： | 王军玲,贾湘曼,鲍春和,陈子明,蒋晔. 阿立哌唑的合成[J]. 中国医药工业杂志, 2004, 35(12): 707-708 |
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| 作者姓名： | 王军玲 贾湘曼 鲍春和 陈子明 蒋晔 |
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| 作者单位： | 河北医科大学药学院,河北,石家庄,050017 |
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| 摘 要： | 间氨基酚和3-氯丙酰氯制得的酰胺在无水三氯化铝作用下环合得7-羟基-3,4-二氢-2(1H)-喹诺酮,与1,4-二溴丁烷成醚后与1-(2,3-二氯苯基)哌嗪进行取代反应制得抗精神病药阿立哌唑,总收率25%.
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| 关 键 词： | 阿立哌唑 抗精神病药 合成 |
| 文章编号： | 1001-8255(2004)12-0707-02 |
Synthesis of Aripiprazole |
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| WANGJun-Ling,JIAXiang-Man,BAO Chun-He,CHEN Zi-Ming,JIANG Ye. Synthesis of Aripiprazole[J]. , 2004, 35(12): 707-708 |
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| Authors: | WANGJun-Ling JIAXiang-Man BAO Chun-He CHEN Zi-Ming JIANG Ye |
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| Affiliation: | WANGJun-Ling,JIAXiang-Man*,BAO Chun-He,CHEN Zi-Ming,JIANG Ye |
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| Abstract: | Aripiprazole was synthesized from 3-aminophenol and 3-chloropropionylchlorideby condensation and cyclization in presence of AlCl3 to give 7-hydroxy-3,4-dihydro-2(1H)-quinolinone, which subjected to etherification with 1,4-dibromobutane and then condensation with 1-(2,3-dichlorophenyl)piperazine in an overallyield of 25%. |
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| Keywords: | aripiprazole antipsychoticdrugs synthesis |
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