The Relationship of pK a and Acute Skin Irritation in Man |
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Authors: | Berner Bret Wilson Donald R Guy Richard H Mazzenga Gerard C Clarke Frank H Maibach Howard I |
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Institution: | (1) CIBA-GEIGY, 444 Saw Mill River Road, Ardsley, New York, 10502;(2) Department of Dermatology, University of California Medical School, San Francisco, California, 94143;(3) Department of Pharmacy and Pharmaceutical Chemistry, University of California, San Francisco, California, 94143 |
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Abstract: | The relationship between pK
a and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15–88 µg/cm2/hr). Skin irritation and pK
a are correlated for pK
a 4. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pK
a, erythema at 24 hr appears to be the most sensitive parameter to variation in pK
a when pK
a 4. |
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Keywords: | skin irritation pK
a pH skin permeation chemical structure/irritation |
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