2型糖尿病患者免疫功能变化与血糖和胰岛素水平相关性的研究

探讨2型糖尿病患者免疫功能变化及其与血糖和胰岛素的相关性.检测34例2型糖尿病(T2DM)患者在空腹和口服75克葡萄糖后120min时的红细胞C3b受体花环(RBC-C3bRR)、红细胞免疫复合物花环(RBC-ICR)、T淋巴细胞亚群(CD3、CD4、CD8、CD4/CD8)、可溶性白介素-2受体(sIL-2R)、免疫球蛋白(IgG、IgA、IgM)、血糖和胰岛素.对照组30名.2型糖尿病患者与对照组相比,RBC-C3bRR、CD3、CD4、CD4/CD8和IgG、IgA均明显降低(P＜0.01,P＜0.05),而RBC-ICR、sIL-2R和CD8明显增高(P＜0.01,P＜0.05),服葡萄糖后120min时较空腹时更明显.RBC-C3bRR与血糖和胰岛素呈负相关(r1=-0.354,r2=-0.335,P＜0.05);RBC-ICR与血糖和胰岛素呈正相关(r3=0.368,r4=0.342,P＜0.05);CD3、CD4、CD4/CD8、IgA与血糖呈负相关(r5=-0.302,r6=-0.378,r7=-0.413,P＜0.01;r8=-0.332, P＜0.01);CD8和sIL-2R与血糖呈正相关(r9=0.214,P＜0.05;r10=0.437,P＜0.01).T2DM患者存在多项免疫指标变化,其免疫功能低下与血糖和胰岛素升高有相关性.

Study on the Changes in Immune Function and Its Correlation with the Levels of Blood Glucose and Insulin in Patients with Type 2 Diabetes Mellitus

To investigate the changes in immune function and its correlation with the levels of blood glucose and insulin in patients with type 2 diabetes mellitus(T2DM), the red cell C3b receptor rosette (RBC-C3bRR), red cell immune complex rosette(RBC-ICR), T-1ymphocyte subpopulations (indirect immunofluorescence assay), soluble interleukin-2 receptor (sandwich enzyme immunosorbent assay) and immunoglobulin were measured in these 34 patients, when they were fasting and at 120 minutes after having 75g glucose, and 30 normal adults were as control. The RBC-C3bRR, CD3, CD4, CD4/CD8 and IgG, IgA in patients with T2DM were significantly lower than that in the control group ( P <0.01, P <0.05). RBC-ICR, sIL-2R and CD8 wre remarkably higher in the patients with T2DM than that in the control group ( P <0.01, P <0.05). RBC-C3bRR exhibited a negative linear correlation with blood glucose and insulin ( r 1=-0.354, r 2=-0.335, P <0.05);RBC-ICR exhibited a positive linear correlation with blood glucose and insulin ( r 3=0.368, r 4=0.342, P <0.05);CD3, CD4, CD4/CD8, IgA exhibited a negative linear correlation with blood glucose ( r 5=-0.302, r 6=-0.378, r 7=-0.413, P <0.01; r 8=-0.332, P < 0.01); CD8 and sIL-2R exhibited a positive linear correlation with blood glucose ( r 9=0.214, P <0.05; r 10=0.437, P <0.01). The immune function of patients with T2DM were lower than those in control groups, including the erythrocyte adhesive function, T-1ymphocyte subpopulations, sIL-2R and immunoglobulin. The changes of these parameters were significantly linear correlation with blood glucose and insulin.