Early gastric cancer combined with multiple metachronous osteosclerotic bone and bone marrow metastases that responded to chemoradiotherapy |
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Authors: | Masaaki Saito Hirokazu Kiyozaki Fumihiro Chiba Osamu Takata Takayoshi Yoshida Chio Shuto Shigeki Yamada Fumio Konishi |
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Institution: | (1) Department of Surgery, Jichi Medical University Saitama Medical Center, Amanuma-cho 1-847, Omiya-ku, Saitama, Japan;(2) Department of Pathology, Jichi Medical University Saitama Medical Center, Saitama, Japan;(3) Department of Surgery, Ogano Municipal Central Hospital, Saitama, Japan |
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Abstract: | We report a 75-year-old woman who suffered multiple metachronous osteosclerotic bone metastases 4 years after a distal gastrectomy
for early gastric cancer (EGC). The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal
layer, and only one lymph node metastasis was noted. To the best of our knowledge, cases of EGC combined with metachronous
osteosclerotic multiple bone and bone marrow metastases that respond to chemoradiotherapy are very rare. In this case, the
multiple bone metastases were diagnosed 4 years after surgery. The patient’s metastatic tumor was successfully treated using
S-1, paclitaxel, and camptothecin, with subsequent irradiation. The patient survived for 24 months after the treatment, without
having any major symptoms. |
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Keywords: | |
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