无抽搐电休克对精神分裂症患者血清IL-6的影响及临床意义

目的：探讨无抽搐电休克（MECT）对精神分裂症患者血清IL-6水平的影响及与精神症状变化的关系。方法：选择符合CCMD-3标准及MECT治疗条件的住院患者31例作为研究组，分别于治疗前、治疗第4次、第8次后测定血清IL-6水平，并用PANSS量表评估精神症状。选择20例健康志愿者作为对照组。结果：IL-6水平在各个时段研究组均比对照组高（t=22．229，23．935，23．085，P均〈0．05），研究组在各个时段IL-6值的变化无区别（F=1．458，P=0．238），研究组在各个时段的IL-6值和PANSS评分无相关性（总分）（r=0．257，0．216，0．268，P均〉0．05），随着治疗的进展PANSS评分明显下降（P均〈0．05）。结论：MECT对精神分裂症患者血清IL-6水平无影响，IL-6水平与精神症状变化无关系。

Effects of MECT on serum IL-6 and clinical significance in Signinficance in schizophrenics

Objective:To explore the effects of modified electro convulsive therapy(MECT) on serum IL-6 and its relationship to changes of psychiatric symptoms in schizophrenics.Methods:31 in patients meeting the CCMD-3 criteria and MECT treatment conditions were selected as research group and 20 healthy volunteers as control group,and serum IL-6 levels were measured and psychiatric symptoms assessed with the Positive and Negative Syndrome Scale(PANSS) before treatment and after the 4thand 8thtreatment.Results:IL-6 levels of each chron-section were higer in the research than in the control group(all P<0.05);in the research group,there were no differences in each chron-section changes(P=0.238),each chron-section values not related to the scores of PANSS(all P>0.05) and the PANSS scores significantly lowered along with therapeutic advancement.Conclusion:The MECT has no effects on serum IL-6 levels which aren't reated to the changes of psychiatric symptoms in schizophrenics.