| 烧伤创面羟脯氨酸含量动态变化的实验研究 |
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| 引用本文： | 方勇,陈玉林,胡云凤,葛绳德. 烧伤创面羟脯氨酸含量动态变化的实验研究[J]. 中华烧伤杂志, 1996, 0(1) |
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| 作者姓名： | 方勇 陈玉林 胡云凤 葛绳德 |
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| 作者单位： | 第二军医大学长海医院烧伤科，第二军医大学长海医院烧伤科，第二军医大学长海医院烧伤科，第二军医大学长海医院烧伤科 200433 上海，200433 上海，200433 上海，200433 上海 |
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| 摘 要： | 为探讨浅Ⅱ度烧伤创面胶原含量的变化及其与创面上皮化的关系,我们对浅Ⅱ度烧伤创面的羟脯氨酸(OHP)水平及创面的形态学变化作了动态检测。结果发现烧伤后早期创面表皮缺损,OHP含量增高,伤后第3天达峰值,继之随着上皮化的完善,OHP 水平逐渐下降至正常。我们认为,浅Ⅱ度烧伤创面胶原的含量与上皮化程度有关,良好的上皮化过程有利于控制胶原的过度增生。表皮细胞源因子(EDF)可能是表皮细胞调控抑制胶原合成的主要因素。
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| 关 键 词： | 烧伤 创面愈合 胶原 羟脯氨酸 |
The dynamic change in the levels of hydroxyproline in the burned wound. |
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| Fang Yong,Chen Yulin,Hu Yunfeng,et al.. The dynamic change in the levels of hydroxyproline in the burned wound.[J]. Chinese journal of burns, 1996, 0(1) |
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| Authors: | Fang Yong Chen Yulin Hu Yunfeng et al. |
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| Affiliation: | Fang Yong,Chen Yulin,Hu Yunfeng,et al.Burn Institute,the Second Military Medical University,Shanghai 200433 |
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| Abstract: | Hydroxyproline,the main component of collagen,and morphological changes were as- sayed dynamically in the superficial second-degree burn wounds of rats,with the aim to investigate the change in collagen and its relationship with epidermization of burn wound.The results are as follows. Epidermal layer was lacking and higher levels of OHP were noted in the early days postburn,OHP peaked on the 3rd day,declined to normal on day 10 and day 14 postburn,the latter event was in pace with the epidermization of the burn wound.These results indicated that the levels of collagen in the su- perficial second-degree burn wound were mainly regulated by epidermal cells.Epidermization might in- hibit over-proliferation of collagen.Epidermal derived factor(EDF)might be the main factor regulating the synthesis of collagen in the superficial second-degree burn wound. |
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| Keywords: | Burn Wound healing Collagen Hydroxyproline |
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