| 姜黄素口服纳米晶胶囊的制备及体内外评价 |
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| 引用本文： | 彭一凡,王增明,王荣荣,杜祎萌,高翔,郑爱萍,张慧. 姜黄素口服纳米晶胶囊的制备及体内外评价[J]. 中国药科大学学报, 2021, 52(2): 211-218 |
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| 作者姓名： | 彭一凡 王增明 王荣荣 杜祎萌 高翔 郑爱萍 张慧 |
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| 作者单位： | 军事科学院军事医学研究院毒物药物研究所,北京 100850,军事科学院军事医学研究院毒物药物研究所,北京 100850,军事科学院军事医学研究院毒物药物研究所,北京 100850;华北理工大学药学院,唐山 063210,军事科学院军事医学研究院毒物药物研究所,北京 100850,军事科学院军事医学研究院毒物药物研究所,北京 100850,军事科学院军事医学研究院毒物药物研究所,北京 100850,军事科学院军事医学研究院毒物药物研究所,北京 100850 |
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| 基金项目： | 国家自然科学基金资助项目（No.81573357,No.82073793） |
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| 摘 要： | 通过纳米晶技术将难溶性药物姜黄素制备成方便给药的口服纳米晶固体制剂,以提高姜黄素的溶解度及溶出速率,进而提高生物利用度.采用介质研磨法制备姜黄素纳米晶混悬液,得到两种稳定的姜黄素纳米晶混悬液处方,稳定剂分别为聚乙烯吡咯烷酮(PVP K30)/十二烷基硫酸钠(SDS)(1∶1),以及吐温80;通过流化床底喷包衣工艺将姜黄...
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| 关 键 词： | 姜黄素 纳米晶 稳定性 介质研磨 底喷包衣 |
| 收稿时间： | 2020-12-29 |
| 修稿时间： | 2021-04-09 |
Preparation and in vitro and in vivo evaluation of oral curcumin nanocrystalline capsules |
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| PENG Yifan,WANG Zengming,WANG Rongrong,DU Yimeng,GAO Xiang,ZHENG Aiping and ZHANG Hui. Preparation and in vitro and in vivo evaluation of oral curcumin nanocrystalline capsules[J]. Journal of China Pharmaceutical University, 2021, 52(2): 211-218 |
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| Authors: | PENG Yifan WANG Zengming WANG Rongrong DU Yimeng GAO Xiang ZHENG Aiping ZHANG Hui |
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| Affiliation: | China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850,China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850,China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850;School of Pharmacy, North China University of Science and Technology, Tangshan 063210, China,China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850,China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850,China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850,China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850 |
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| Abstract: | |
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| Keywords: | curcumin nanocrystalline stability media grinding bottom spray coating |
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