| 一氧化氮供体型心脑血管药物研究的实践与思考 |
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| 引用本文： | 吴建兵,黄张建,张奕华. 一氧化氮供体型心脑血管药物研究的实践与思考[J]. 中国药科大学学报, 2021, 52(2): 129-143 |
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| 作者姓名： | 吴建兵 黄张建 张奕华 |
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| 作者单位： | 中国药科大学新药研究中心,南京 210009,中国药科大学新药研究中心,南京 210009,中国药科大学新药研究中心,南京 210009 |
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| 基金项目： | 国家自然科学基金资助项目（No.81773573,No.81822041,No.81673305,No.81273378,No.81202408,No.39770869,No.30973608,No.30472085,No.30271491,No.21372261）;“重大新药创制”科技重大专项资助项目（No.2009ZX09103-095,No.2009ZX09103-090） |
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| 摘 要： | 一氧化氮(nitric oxide,NO)作为信使物质和/或效应分子在心血管、神经、免疫等系统中发挥着极其重要的作用.NO生成不足或信号传导异常与多种疾病的形成和发展密切相关,直接或间接调控体内NO水平及其相关代谢途径的研究已成为生物医学和药学领域研究的热点.本文介绍了体内NO的产生及其在心脑血管中的生理、病理作用,综...
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| 关 键 词： | 一氧化氮(NO) NO供体型心脑血管药物 生理/病理作用 效应分子 信使物质 |
| 收稿时间： | 2021-01-09 |
| 修稿时间： | 2021-02-15 |
Research and reflections on the nitric oxide-donating cardio-cerebrovascular drugs |
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| WU Jianbing,HUANG Zhangjian and ZHANG Yihua. Research and reflections on the nitric oxide-donating cardio-cerebrovascular drugs[J]. Journal of China Pharmaceutical University, 2021, 52(2): 129-143 |
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| Authors: | WU Jianbing HUANG Zhangjian ZHANG Yihua |
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| Affiliation: | Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China,Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China,Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Nitric oxide (NO) as a signal transduction species and/or effector molecule plays an extremely important role in the cardiovascular, nervous, and immune systems. Insufficient production or abnormal signal transduction of NO is closely associated with onset and progression of many diseases. Studies on direct or indirect regulation of NO levels in vivo and related metabolic pathways have become a hot spot in biomedical and pharmaceutical fields. This review briefly introduces the generation of NO in vivo and its physiological and pathological functions in cardio-cerebrovascular system, with focus on the authors'' research on NO-donating cardio-cerebrovascular and related drugs, aiming to provide some reference for future development of these drugs. |
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| Keywords: | nitric oxide NO-donating cardio-cerebrovascular drugs physiological and pathological functions effector molecule signal transduction speciesThis work was supported by the National Natural Science Foundation of China (No.81773573, No.81822041, No.81673305, No.81273378, No.81202408, No.39770869, No.30973608, No.30472085, No.30271491, No.21372261), and China National Key Hi-Tech Innovation Project for the R& D of Novel Drugs (No.2009ZX09103-095, No.2009ZX09103-090) |
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