肿瘤患者的耐药菌分布特点

目的:了解肿瘤患者的细菌分布及耐药特点.方法:对天津医科大学肿瘤医院(TMUCH)2016—2018年检出的菌株进行归类分析,并与2016、2017年中国细菌耐药监测(CHINET)报道的细菌耐药率结果进行对比.结果:TMUCH2016—2018年各菌株构成比变化不大.革兰阳性菌耐药率方面,耐苯唑西林金黄色葡萄球菌呈逐...

Distribution Characteristics of Drug-resistant Bacteria in Cancer Patients

Objective To understand the distribution and drug resistance of bacteria in cancer patients.Methods The strains detected in Tianjin Medical University Cancer Hospital(TMUCH)from 2016 to 2018 were classified and analyzed,and the results were compared with the results reported in CHINET2016 and CHINET2017.Results The composition of each strain in TMUCH changed little from 2016 to 2018.As for the drug resistance rate of Gram-positive bacteria,oxacillin-resistant Staphylococcus aureus showed increased year by year,but the overall drug resistance rate was not high and lower than that reported by CHINET;oxacillinresistant coagulase-negative Staphylococcus showed decreased year by year,and there was no significant difference compared with CHINET reports,and they were all at a high drug resistance level.The ampicillinresistant Enterococcus faecalis were increased on the contrary of CHINET reported,but the overall drug resistance rate is low;ampicillin-resistant Enterococcus faecium has not changed in three years,and the overall drug resistance rate is lower than that reported by CHINET,but all of them are at a high level of drug resistance.The main Gram-positive bacteria have no or very few resistant strains to high-level antibiotics commonly used in clinic,such as vancomycin,linezolid and tegacycline.For Gram-negative bacteria,the drug resistance rates of Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii to piperacillin/tazobactam,cefepime,imipenem and tegacycline were lower or equivalent than those reported by CHINET.However,Enterobacter cloacae and Stenotrophomonas maltophilia showed a higher drug resistance rate and an increasing trend year by year,which was higher than that reported by CHINET.Conclusion The distribution of drug-resistant bacteria in cancer patients is different from that in patients with common infection.Antibiotics should be reasonably selected according to their own characteristics.