瑞芬太尼在机械通气患者镇痛镇静中的应用研究

目的:观察瑞芬太尼对重症加强医疗病房(IntensiveCare Unit,ICU)机械通气患者镇痛、镇静的临床疗效及不良反应.方法:选择2017年12月1日至2019年12月25日在甘肃医学院附属医院(原平凉市人民医院)IC U拟行有创机械通气的106名患者,按随机数字表法分为芬太尼组(53例)及瑞芬太尼组(53例)...

Study on the application of remifentanil in analgesia and sedation of patients with mechanical ventilation

Objective:To observe the clinical efficacy and adverse reactions of remifentanil on analgesia and sedation of patients receiving mechanical ventilation in intensive care unit(ICU).Methods:Choose December 1,2017 to December 25,2019 in Pingliang City People's Hospital ICU fitting line of invasive mechanical ventilation,106 patients according to random number table method divided into fentanyl group(53 cases)and remifentanil group(53 cases)were given fentanyl and remifentanil continuous intravenous pumping analgesia,sedation.CPOT,RASS,MAP,HR,SpO2 before and after administration were recorded for patients in the two groups during treatment.Adverse reactions and delirium after administration were observed.Results:The MAP of the fentanyl group was significantly higher than that of the remifentanil group at 30 minutes of medication,and the HR of the remifentanil group was lower than that of the fentanyl group at 30 and 60 minutes of medication(P<0.05),and there was no significant difference in other vital signs.The CPOT in the fentanyl group was significantly higher than that in the remifentanil group at 30 minutes(P<0.05),and there was no significant difference in the depth of analgesia and sedation at other time points.The incidence of delirium and vomiting in the remifentanil group was lower than that in the fentanyl group(P<0.05),and there was no significant difference in the incidence of nausea between the two groups(P>0.05).Conclusion:The efficacy of remifentanil in ICU patients with mechanical ventilation is comparable to that of classical treatment,and its rapid onset can shorten the time of mechanical ventilation and reduce the dosage of sedatives,thus reducing delirium to some extent.