口服中药治疗稳定型心绞痛疗效及安全性的Meta分析

目的:评价口服中药治疗稳定型心绞痛的疗效及安全性.方法:计算机检索国家知识基础设施数据库(简称中国知网,China National Knowledge Infrastructure,CNKI)、中文科技期刊数据库(简称维普资讯,Chinese Citation Database,CCD)、中国学术期刊数据库(简称万方...

Efficacy and Safety of Oral Chinese Medicine in the Treatment of Stable Angina Pectoris:A Meta-analysis

Objective:To evaluate the efficacy and safety of oral Chinese medicine in the treatment of stable angina pectoris.Methods:Electronic databases including CNKI,VIP,Wangfang,PubMed,EMBASE,Cochrane lib,Google and Web of Science were retrieved,the retrieval time was from the establishment of databases to November 1,2019.Reviewers screened out the literature,extracted information,evaluated risk of bias and cross check.Review Manager 5.3 and Stata SE 12 softwares were used for Meta-analysis.Results:A total of 32 studies involving 2746 patients were included,with a total of 34 groups.The results showed that the improvement of angina symptom by Chinese medicine[OR=3.68,95%CI(2.97~4.57),P<0.00001],number of angina attacks[SMD=-0.61,95%CI(-0.82~-0.39),P<0.00001],time of angina attacks[SMD=-0.78,95%CI(-1.16~-0.41),P<0.0001],treadmill exercise test of metablic equivalent[SMD=0.77,95%CI(0.39~1.15),P<0.0001],improving electrocardiogram[OR=2.31,95%CI(1.88~2.82),P<0.00001],improving nitroglycerin deactivation rate[OR=2.42,95%CI(1.81~3.22),P<0.00001],and reducing nitroglycerin consumption[SMD=-0.60,95%CI(-0.96~-0.24),P=0.001]were better than control groups.Fewer adverse events happened in the treatment group[OR=0.49,95%CI(0.27~0.89),P=0.02].Conclusion:The efficacy and safety of oral Chinese medicine for stable angina pectoris are comparatively good,which is worthy of clinical promotion.