| 消瘤汤联合腹腔热灌注化疗干预结直肠癌术后免疫功能和VEGF蛋白表达的影响研究 |
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| 引用本文： | 曾家耀,陈明科,江现强. 消瘤汤联合腹腔热灌注化疗干预结直肠癌术后免疫功能和VEGF蛋白表达的影响研究[J]. 辽宁中医杂志, 2011, 0(4): 595-597 |
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| 作者姓名： | 曾家耀 陈明科 江现强 |
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| 作者单位： | 广西中医学院第一附属医院胃肠腺体外科;广西中医学院; |
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| 基金项目： | 广西科技厅自然基金项目(桂科自0728178); 广西中医药管理局中医药科技专项课题项目(GZKZ09-25) |
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| 摘 要： | 目的:探讨消瘤汤联合腹腔热灌注化疗对术后结直癌患者免疫功能和血清血管内皮生长因子(VEGF)蛋白表达的影响。方法:104例行手术治疗的进展期结直肠癌患者,按随机数字表分为治疗组和对照组,治疗组54例,采用腹腔热灌注化疗同时口服消瘤汤,对照组50例,单用腹腔热灌注化疗方案进行治疗,观察两组生存质量、免疫功能、化疗药物不良反应、血清血管内皮生长因子水平(VEGF)变化及VEGF蛋白表达情况。结果:治疗组生存质量的改善明显优于对照组(P<0.05);治疗组中性粒细胞减少、腹泻程度、神经毒性等与对照组比较有显著性差异(P<0.05)。治疗组治疗前CD4+/CD8+为(1.32±0.28)%,治疗后提高至(1.58±0.27)%,差异有显著性(P<0.05)。两组术前癌组织已浸透浆膜或术前已有局部淋巴结转移者1年及3年的生存率组间差异有显著意义(P<0.05)。治疗前两组VEGF水平比较差异无统计学意义(P>0.05),治疗后两组VEGF水平均下降(P<0.05),且治疗组下降更为显著(P<0.05);治疗组治疗前后血清VEGF蛋白表达明显下降,两组比较差异差异有统计学意义(P<0.05)。结论:消瘤汤联合腹腔热灌注化疗对结直癌术后患者有一定的防治作用,能改善病人生存期质量,其作用机制之一可能是通过抑制血清中VEGF蛋白表达进而抑制肿瘤血管生成、有效减轻化疗药物不良反应、提高CD4+/CD8+比值、增强巨噬细胞的吞噬功能而发挥作用。
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| 关 键 词： | 腹腔热灌注化疗 消瘤汤 血管内皮生长因子 结直肠癌 |
Effects of Xiaoliu Decoction Combined with Hyperthemic Peritoneal Perfusion Chemotherapy on Immune Function and the Protein Expression of Serum Vascular Endothelial Growth Factor in Colorectal Cancer After Surgery Treated |
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| ZENG Jia-yao,CHEN Ming-ke,JIANG Xian-qiang. Effects of Xiaoliu Decoction Combined with Hyperthemic Peritoneal Perfusion Chemotherapy on Immune Function and the Protein Expression of Serum Vascular Endothelial Growth Factor in Colorectal Cancer After Surgery Treated[J]. Liaoning Journal of Traditional Chinese Medicine, 2011, 0(4): 595-597 |
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| Authors: | ZENG Jia-yao CHEN Ming-ke JIANG Xian-qiang |
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| Affiliation: | ZENG Jia-yao1,CHEN Ming-ke2,JIANG Xian-qiang1(1.Department of Glands Gastrointestinal Surgery,The First Affiliated Hospital to Guangxi Traditional Chinese Medicine University,Nanning 530023,Guangxi,China,2.2009 Postgraduate of the Guangxi Traditional Chinese Medicine University,China) |
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| Abstract: | Objective:To evaluate the Effects of xiaoliu decoction combined with hyperthemic peritoneal perfusion chemotherapy on immune function and the protein expression of serum vascular endothelial growth factor in Colorectal cancer after surgery treated.Methods:104 cases with surgical treatment of patients with advanced colorectal cancer were randomly divided into two groups:Treatment Group of 54 patients used to intraperitoneal hyperthermic perfusion chemotherapy,oral Xiaoliu decoction;the control group of 50 pa... |
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| Keywords: | hyperthemic peritoneal perfusion chemotherapy xiao liu decoction VEGF colorectal cancer |
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