EFFECT OF SODIUM NITROPRUSSIDE ON THE BIOPHASE CONCENTRATION OF D-TUBOCURARINE AT THE NEUROMUSCULAR JUNCTION |
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Authors: | P. Chang S. L. Geh |
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Affiliation: | Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia |
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Abstract: | D-Tubocurarine (DTC) at an intravenous dose of 250 micrograms/kg, or at an intra-arterial dose of 25 micrograms/kg, produced about a 50% block on the twitch tension of the indirectly stimulated tibialis anterior muscle of anaesthetized cats. The DTC-induced neuromuscular block was abolished if it was given intravenously but not intra-arterially, 30 min after the commencement of sodium nitroprusside (SNP) infusion (5 micrograms/kg per min) when there was a maximum decrease in blood pressure. The results indicate that the biophase concentration of DTC at the neuromuscular junction may be decreased as a consequence of the vasodilation induced by SNP leading to a reduced transport of the blocker to the site of action. |
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Keywords: | blood pressure, d-tubocurarine, peroneal nerve, sodium nitroprusside, tibialis anterior muscle, twitch tension. |
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