沙培林联合腹腔内低渗温热化疗在胃癌根治术中的临床研究

目的：探讨术前腹腔注射沙培林联合术中腹腔内温热化疗（IPHHOI）治疗进展期胃癌的II缶床疗效及安全性。方法：胃癌患者40例（实验组）术前腹腔注射沙培林联合术中腹腔内温热化疗（IPHHOI）；39例（对照组）单纯手术。随访3年生存率及预后。结果：试验组3年生存率85％明显高于对照组69．02％（P〈0．05）；其中由于淋巴转移和腹膜种植转移而造成的死亡率明显下降（P〈0．05）；手术并发症发生率2组差异无显著性（P〉0．05）。结论：胃癌患者采用沙培林联合腹腔内低渗温热化疗，可预防术后淋巴结转移和腹膜种植转移的发生，提高术后生存率，是一种安全有效的方法。

Clinical study of intraperitoneal injection of sapylin combined with intraperitoneal hyperchemic hypo- osmolar infusion during radical gastrectomy

Objective：To evaluate the clinical effect and safety of intraperitoneal injection of sapylin combined with intraperitoneal hyperchemic hypo - osmolar infusion during radical gastrectomy. Methods： Forty cases of gastric cancer in the experimental group were treated with intraperitoneal injection of sapylin combined with intraperitoneal hyperchemic hypo - osmolar infusion in radical gastrectomy; the other 39 cases in the control group received only radical gastrectomy. The follow - up results and results were compared between two groups. Results： The three year survival rates were $5% and 69.02% in experimental group and control group,respectively （ P 〈0.05 ）. Death rates due to recurrence of lymph nodes and peritoneum were decreased significantly. The difference of the morbidity of postoperative complications between two groups was not significant （ P 〉 0.05 ）. Conclusion： The survival rates can be improved and recurrence of lymph nodes and peritoneum can be reduced in gastric carcinoma by intraperitoneal injection of sapylin combined with intraperitoneal hyperchemic hypo - osmolar infusion in radical gastrectomy. It is a safe and effective method.