| p27kip1在胃癌中的表达及其意义 |
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| 引用本文： | 周琪,张中乐,徐川,权松霞,吉巧红.p27kip1在胃癌中的表达及其意义[J].河南科技大学学报(医学版),2004,22(4):247-248. |
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| 作者姓名： | 周琪 张中乐 徐川 权松霞 吉巧红 |
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| 作者单位： | 河南科技大学医学院,河南洛阳,471003 |
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| 摘 要： | 目的研究p27kip1在胃癌中的表达及其意义.方法应用免疫组化SP法检测胃癌组织中p27kip1的表达.结果本组58例胃癌中,p27kip1
的阳性率为50%,12例胃良性病变中p27kip1 的阳性率为100%,p27kip1与胃癌的组织学分类、浸润深度、淋巴结转移、临床分级均呈负相关(P<0.05).结论胃癌p27kip1蛋白表达降低与肿瘤低分化和肿瘤进展有关,可作为预测胃癌预后的重要指标.
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| 关 键 词： | 胃癌 p27^kip1 免疫组织化学 基因表达 肿瘤低分化 |
| 文章编号： | 1672-688X(2004)04-0247-02 |
| 修稿时间： | 2004年8月4日 |
The Significance and Expression of p27kip1 in Gastric Carcinoma |
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| ZHOU Qi,ZHANG Zhong-le,XU Chuan,et al.The Significance and Expression of p27kip1 in Gastric Carcinoma[J].Journal of Henan University of Science & Technology:Medical Science,2004,22(4):247-248. |
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| Authors: | ZHOU Qi ZHANG Zhong-le XU Chuan |
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| Abstract: | Objective To study the significance and the expression of p27 kip1in gastric carcinoma. Methods Histochemical SP was used to detect the expression of p27 kip1in gastric carcinoma. Result The positive rate of p27 kip1expression in gastric carcinoma was 50% and 100% in stomach benign disease respectively.p27 kip1expression level was correlated with the degree differentiation,histological grade, invasive depth,lymph node metastasis and TNM stage (P<0.05). Conclusion The reduced expression of p27 kip1 is significantly associated with the poor differentiation and progression of gastric carcinoma.It may be an important factor for prognosis of gastric carcinoma. |
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| Keywords: | gastric carcinoma p27 kip1 immunohistochemistry expression |
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