High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania |
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Authors: | Hoelscher M Kim B Maboko L Mhalu F von Sonnenburg F Birx D L McCutchan F E;UNAIDS Network for HIV Isolation and Characterization |
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Institution: | Department of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-University, Munich, Germany. |
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Abstract: | BACKGROUND: In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s. OBJECTIVE: To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form. METHODS: Nine HIV-1-seropositive young adults from Mbeya Town with no evident high-risk behaviour contributed peripheral blood mononuclear cells for this study. Nine virtually full-length-genome-sequences were amplified from this DNA and phylogenetically analysed. RESULTS: Out of the nine samples, two were subtype A (22%), two were subtype C (22%) and five were recombinants (56%): four A/C recombinants and one C/D recombinant. None of the recombinants were related to each other; all of them had different mosaic structures. Most of the genome in the recombinants was subtype C. CONCLUSION: A high proportion of unrelated intersubtype recombinants, none of them apparently spreading in the population, may be present in southwest Tanzania. |
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