Effect of mesenchymal stem cell transplantation on cognitive functions in rats with ischemic stroke |
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| Authors: | I. B. Sokolova O. R. Fedotova N. N. Zin’kova P. V. Kruglyakov D. G. Polyntsev |
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| Affiliation: | (1) Trans-Tekhnologiya Company, Russia;(2) Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg |
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| Abstract: | The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem cells 3 days after middle cerebral artery occlusion reduced the area of cerebral injury, preserved cognitive functions, and decreased mortality in experimental animals. __________ Translated from Kletochnye Tekhnologii v Biologii i Medicine, No. 4, pp. 202–205, December, 2006 |
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| Keywords: | mesenchymal stem cells ischemic stroke cognitive functions |
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