| 增殖细胞核抗原在垂体腺瘤中的表达及其与复发的关系 |
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| 引用本文： | 熊志阳,李美华,李义云.增殖细胞核抗原在垂体腺瘤中的表达及其与复发的关系[J].江西医学院学报,2006,46(5):71-72,75. |
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| 作者姓名： | 熊志阳 李美华 李义云 |
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| 作者单位： | 南昌大学第一附属医院神经外科,南昌330006 |
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| 摘 要： | 目的通过检测增殖细胞核抗原（PCNA）在垂体腺瘤中的表达来探讨它与垂体腺瘤侵袭和增殖能力及复发的关系。方法收集垂体腺瘤标本60例，其中侵袭性和非侵袭性垂体腺瘤分别为30例和25例，复发性垂体腺瘤（非侵袭性）5例。采用免疫组化方法检测PCNA在垂体腺瘤中的表达。结果PCNA在侵袭性垂体腺瘤中的表达水平显著高于非侵袭性垂体腺瘤；PCNA表达阳性率侵袭性与非侵袭性垂体腺瘤分别为50％和16％，复发性与非复发性垂体腺瘤分别为80％和34．6％，差异均有显著性（P〈0．01，P〈0．05）。结论PCNA与垂体腺瘤侵袭、增殖能力及术后复发密切相关。
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| 关 键 词： | 垂体腺瘤 增殖细胞核抗原 免疫组织化学 |
| 文章编号： | 1000-2294（2006）05-0071-02 |
| 收稿时间： | 05 8 2006 12:00AM |
| 修稿时间： | 2006-05-08 |
Expression of PCNA in Pituitary Adenoma and Its Relation to Tumor Recurrency |
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| XIONG Zhi-yang,LI Mei-hua,LI Yi-yun.Expression of PCNA in Pituitary Adenoma and Its Relation to Tumor Recurrency[J].Acta Academiae Medicinae Jiangxi,2006,46(5):71-72,75. |
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| Authors: | XIONG Zhi-yang LI Mei-hua LI Yi-yun |
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| Institution: | Department of Neurosurgery , The First Affiliated Hospital of Nanchang University ,Nanchang 330006,China |
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| Abstract: | Objective To investigate the expression of PCNA in human pituitary adenomas and its relation to tumor invasivenes, proliferation and recurrency. Methods Immunohistochemical techniques were used to detect the expression of PCNA in cases of invasive, non-invasive and recurrent pituitary adenomas. Results The expression of PCNA increased significantly in invasive pituitary adenomas group than that in non-invasive group and again the expression of recurrent group increased significantly than that in non-recurrent group. Conclusion The expression of PCNA correlates closely with the invasiveness ,proliferation and recurrency in patients with pituitary adenomas. |
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| Keywords: | pituitary adenoma PCNA immunohistochemistry |
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