| Abstract: | In the rat intestine nitrazepam is transformed to an amine and acetamide. In the duodenum and small intestine the reduction of nitrazepam and its subsequent acetylation are catalyzed by enzymes in the mucosa. In the cecum and large intestine these processes are due to the action of the microflora and tissue enzymes, and in the rectum to the action of the microflora alone.Laboratory of Psychotropic Preparations, I. I. Mechnikov Odessa University. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 7, pp. 53–56, July, 1977. |
