Ceramides modulate programmed cell death in plants |
| |
Authors: | Liang Hua Yao Nan Song Jong Tae Luo Song Lu Hua Greenberg Jean T |
| |
Institution: | Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA. jgreenbe@midway.uchicago.edu |
| |
Abstract: | The balance between the bioactive sphingolipid ceramide and its phosphorylated derivative has been proposed to modulate the amount of programmed cell death (PCD) in eukaryotes. We characterized the first ceramide kinase (CERK) mutant in any organism. The Arabidopsis CERK mutant, called accelerated cell death 5, accumulates CERK substrates and shows enhanced disease symptoms during pathogen attack and apoptotic-like cell death dependent on defense signaling late in development. ACD5 protein shows high specificity for ceramides in vitro. Strikingly, C2 ceramide induces, whereas its phosphorylated derivative partially blocks, plant PCD, supporting a role for ceramide phosphorylation in modulating cell death in plants. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|