2型糖尿病患者血清巨噬细胞抑制因子-1与颈动脉粥样斑块相关性的观察

目的 探讨T2DM患者血清巨噬细胞抑制因子-1（MIC-1）与颈动脉粥样斑块的相关性.方法 根据多普勒超声结果,将113例T2DM患者分为合并颈动脉粥样斑块组（A,n=55）与单纯T2DM组（B,n=58）,另选正常对照组（C,n=57）.ELISA测定研究对象血清MIC-1水平. 结果 A、B组血清MIC-1水平高于C组（P＜0.01）,A组高于B组（P＜0.01）.相关分析显示,血清MIC-1水平与FPG、HbA1 c、SBP、DBP、TG、肿瘤坏死因子α（TNF-α）呈正相关（r=0.183、0.287、0.173、0.194、0.270、0.287,P＜0.05）,与HDL-C呈负相关（r=-0.410,P＜0.01）.多元线性逐步回归分析表明,HbA1 c、TG、HDL-C是血清MIC-1水平的独立影响因素（β=0.204、0.176、0.296,P＜0.05）. 结论 T2DM患者血清MIC-1水平升高,T2DM合并颈动脉粥样斑块患者血清MIC-1水平较单纯T2DM患者进一步升高.HbA1c、TG、HDL-C是MIC-1的独立相关因素.

Observation on the relationship between serum macrophage inhibitory cytokine-1 and carotid plaque in type 2 diabetic patients

Objective To explore the correlation between serum macrophage inhibitory cytokine-1 （MIC-1） and carotid plaque in type 2 diabetic patients.Methods A total of 113 cases was divided into two groups：T2DM patients with carotid plaque group（A,n=55）,and without carotid plaque group（B,n=58） according to the results of Doppler echocardiography.Fifty-seven healthy people were selected as normal control group （C,n=57）.Serum MIC-1 levels were detected by ELISA.Results The levels of MIC-1 in group A and B were significantly higher than in group C （P＜0.01）.Compared with group B,the level of MIC1 in group A was increased（P＜0.01）.Correlation analysis showed that serum MIC-1 levels was positively correlated with fasting plasma glucose、glycosylated hemoglobin A1c （HbA1c）、systolic blood pressure （SBP）、diastolic blood pressure（DBP）、triglycerides （TG） 、tumor necrosis factor-α （r =0.183,0.287,0.173,0.194,0.270,0.287,P＜0.05）,and it was inversely related to high-density-lipoprotein cholesteROl（HDL-C）（r=-0.410,P＜0.01）.Stepwise linear multiple regression analysis showed that HbA1c,TG and HDL-C were the independent factors of serum MIC-1（β=0.204、0.176、-0.296,P＜0.05）.Conclusion The levels of serum MIC-1 in T2DM patients are higher,and they are even higher in T2DM patients with carotid plaque.HbA1 c,TG and HDL-C are the independent correlative factors of serum MIC-1.