芦笋、香菇、绿豆对小白鼠实验性高脂血症的预防作用

目的 :研究芦笋、香菇、绿豆对小白鼠实验性高脂血症的预防作用。方法 :静脉注射四氧嘧啶和腹腔注射 75 %蛋黄乳液造成小白鼠实验性高脂血症和高血糖模型 ,用芦笋、香菇和绿豆进行治疗。结果 :芦笋香菇汁、芦笋香菇绿豆汁均可显著降低实验性高脂血症小白鼠的血清甘油三脂 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)及血糖 (BG)浓度 ,显著增高血清高密度脂蛋白胆固醇 (HDL -C)浓度 (P <0 .0 1 ) ,作用程度与已知降脂、降糖药物相当。结论 :芦笋香菇汁、芦笋香菇绿豆汁均能抑制小白鼠实验性高脂血症的形成。

The Preventive Effect of Asparagus and Lentinus and Mung Bean on Experimental Hyperlipidemia in Mice

In order to investigate the effect of Chinese thorowax root and turmeric on hyperlipidemia, the experiment was conducted as follows: An animal model of hyperlipidemia and hyperglycemia was established by treating normal Kunming mice with alloxan (iv) and yold (ip). 120 normal Kunming mice were divided into five groups: Control group (C); Model group (N); Positive control group (P); Asparagus and lentinus group (AL); Asparagus and lentinus and mung bean group (ALM). C and M were given normal saline, AL group was given asparagus and lentinus mixed juice, ALM group was given asparagus and lentinus and mung bean mixed juice, P group was given Fenofibrate and Metformin (300mg/kg respectively). All of the experimental liquid were given by gavage once a day, at dose of 0.03mg/g body weight for 30 days. The results indicated: compared with M group, the serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and blood glucose (BG) in AL, ALM and P group decreased, the high density lipoprotein (HDL-C) increased significantly (P<0.01). Compared with P group, the serum TC, TG and LDL-C in AL and ALM group decreased much more, the serum HDL-C increased significantly (P<0.01). It is suggested that: the asparaguas and lentinus mixed juice, asparaguas and lentinus and mung bean mixed juice may prevent and cure experimental hyperlipidemia, and keep the serum HLD-C at a normal level.