TK1、Ki-67、p53在乳腺癌组织中的表达与及其预后的关系

目的：探讨TK1、Ki-67、p53在乳腺癌组织中的表达及其与预后的关系。方法：2009年3月—2013年5月收治的60例乳腺癌患者，均接受乳腺癌根治术并留取组织标本，用免疫组化法检测乳腺癌组织及其癌旁组织中TK1、Ki-67和p53的表达；根据随访资料分析TK1、Ki-67和p53的表达与患者预后的关系。结果：乳腺癌组织中TK1、Ki-67、p53阳性率均明显高于癌旁组织（均P<0.05）；TK1、Ki-67、p53的表达强度明显影响患者的5年生存率，均表现为表达强度越高患者的生存率越低（均P<0.05）；TK1、Ki-67和p53表达的阳性率在术后5年内出现复发或转移的患者中均明显高于无复发或转移的患者（均P<0.05）。结论：在乳腺癌组织中TK1、Ki-67和p53表达增强，且其表达强度与乳腺癌的不良预后密切相关。

Expressions of TK1, Ki-67 and p53 in breast cancer and their relations with prognosis

Objective: To observe the expression of TK1, Ki-67 and p53 in breast cancer (BC) and their prognosis.Methods: Sixty patients with breast cancer admitted from March 2009 to May 2013 underwent radical mastectomy and their histological specimens were obtained. The expressions of TK1, Ki-67 and p53 in these breast cancer tissues and their adjacent tissues were examined by immunohistochemical staining, and in combination with the follow-up data, the relations of TK1, Ki-67 and p53 expression with the prognosis of the patients were analyzed.Results: The positive expression rates of TK1, Ki-67 and p53 in breast cancer tissues were all significantly higher than those in their adjacent tissues (all P<0.05). The expression intensities of TK1, Ki-67 and p53 markedly affected the 5-year survival rate of the patients, which all indicated that the higher the expression intensity, the lower the survival rate (all P<0.05). The positive expression rates of TK1, Ki-67 and p53 in patients with recurrence or metastasis within 5 years were significantly higher than those in patients without recurrence or metastasis.Conclusion: The expressions of TK1, Ki-67 and p53 are enhanced in breast cancer tissue, and their expression intensities are closely associated with unfavorable prognosis of the patients.