First trimester serum inhibin A in normal pregnant women |
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Authors: | Vorapong Phupong Tharangrut Hanprasertpong Sittisak Honsawek |
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Institution: | (1) Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Pathumwan, Bangkok, 10330, Thailand;(2) Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand |
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Abstract: | Objectives To establish reference ranges for maternal serum inhibin A in normal first trimester pregnant women.
Materials and methods This was a cross-sectional study. We measured maternal serum inhibin A in normal pregnant women gestation age between 6+0 and 14+6 weeks using the enzyme-linked immunosorbent assay (ELISA) method. Maternal serum inhibin A was analyzed according to gestational
ages (GA).
Results Serum of 300 pregnancies was analyzed and the outcome demonstrated the median of maternal serum inhibin A according to gestational
age. The levels of maternal serum inhibin A during the 60–6+6 week of gestations are lowest when compared with other gestational age. The levels of maternal serum inhibin A during 90–9+6 week of gestations are maximal. Maternal serum inhibin A then declined until 14 weeks of gestation.
Conclusion Serum inhibin A can be measured during the first trimester of pregnancy by using the recent ELISA technique. Our reference
ranges might be useful for further studies, such as prediction of adverse pregnancy outcome in threatened abortion. |
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Keywords: | Serum inhibin A First trimester Pregnancy Normal ELISA |
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