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评估GFR的新型标志物血清胱抑素C的临床应用研究
引用本文:王亚平,张宇梅,霍延红,杨永红,张文博,李浩,刘洪涛,刘力瑞. 评估GFR的新型标志物血清胱抑素C的临床应用研究[J]. 解放军保健医学杂志, 2009, 0(4): 280-281
作者姓名:王亚平  张宇梅  霍延红  杨永红  张文博  李浩  刘洪涛  刘力瑞
作者单位:北京军区总医院肾脏病科;
摘    要:目的同时检测血清胱抑素C(Cystatin C,CystC)与内生肌酐清除率(Ccr)并进行对比分析,验证其相关性、准确性,探讨CystC评估肾小球滤过率(GFR)的临床实用价值。方法选择在肾脏病科住院09231例慢性肾脏病患者,其中男126例.女105例。年龄18~82岁,平均年龄48.75±18岁。应用西门子德灵诊断产品有限公司生产的BNP特定蛋白自动分析系统及试剂盒测定CystC,并同时检测Ccr。结果231例慢性肾脏病患者的CystC与Ccr呈显著负相关(r=-0.386,P〈O.01),CystC随着Ccr的下降而升高,各组间比较。差异有统计学意义(P〈O.01)。结论CystC可以单独作为评价GFR的敏感指标.比Ccr更客观地反映肾功能损伤不同时期GFR的功能。为在手术、使用造影剂、调整用药之前等急需了解肾功能状态时,提供了一个简便、准确、敏感地反映GFR的指标。

关 键 词:血清胱抑素C  肾小球滤过率  慢性肾脏病

Clinical application study of Cystatin C the new marker evaluation GFR
WANG Yaping,ZHANG Yumei,HUO Yanhong,YANG Yonghong,ZHANG Wenbo,LI Hao,LIU Hongtao,LIU Lirui. Clinical application study of Cystatin C the new marker evaluation GFR[J]. Journal Of Health Care And Medicine in Chinese Pla, 2009, 0(4): 280-281
Authors:WANG Yaping  ZHANG Yumei  HUO Yanhong  YANG Yonghong  ZHANG Wenbo  LI Hao  LIU Hongtao  LIU Lirui
Affiliation:Department of Nephrology;the Military General Hospital of Beijing 100700;China
Abstract:Objective To investigate clinical significance of sera level of cystatin C,compared to Ccr,in the evaluation of glomerular filtration rate(GFR). Methods 231 hospitalized patients(126 men and 105 women;aged from 18 to 82)with chronic kidney disease(CKD)were selected. The serum Cystain-C and Ccr were detected. Results In 231 CKD patients,serum Cystain-C is significantly correlated reversely with Ccr (r=-0.386,P<0.01). Ccr decreased while serum Cystain-C increased. In different 5 groups, the level of serum Cys...
Keywords:Serum cystatin-C  Renal function  Chronic kidney disease  
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