脑新肽和电针镇痛

脑新肽是从人脑中分离得到的一个阿片样四肽,它有很强的镇痛作用,它不但存在于人脑中,也存在于兔脑中。针刺镇痛时,家兔中央灰质中脑新肽的释放增加,痛阈亦增加。针刺前中央灰质灌流中脑新肽的含量为5.8±0.4毫微摩/毫升;针刺30分钟后,灌流液中的含量为10.6±0.9毫微摩/毫升;平均增加4.8±0.6毫微摩/毫升。说明针刺镇痛与脑新肽的释放有关。针刺镇痛时,家兔脑脊液中脑新肽的含量,随着针刺时间的延长而增加,痛阈亦随着针刺时间的延长而升高。

NAGA PEPTIDE AND ELECTRO-ACUPUNCTURE ANALGESIA

1. The release of Naga peptide in central grey of rabbit was incread signifi- cantly after acupuncture. 2. The content of Naga peptide in CSF was increased markedly after acupuncture, and the pain threshold of the rabbit was also increased, markedly at the same time. The increment of Naga was parallel to the rise of pain thrashold. 3. The amount of Naga peptide in CSF was increased markedly after injection of Naga ino the vein and the Pain threshold of the rabbit was also increased markedly at the same time. The increment of Naga in CSF was parallel to the rise of pain threshold. 4. Naga peptide in CSF was increased markedly after acupuncture,or increased significantly after injection into the vein. The changes of Naga in CSF were parallel to the changes of pain threshold. Thes results show that Naga may be one of the endogenous opioid peptide and related to the acupuncture.