| 线粒体蛋白Smac/DIABLO与肿瘤 |
| |
| 引用本文： | 曾辉,黄绪群[综述],伍钢,龙志雄[审校]. 线粒体蛋白Smac/DIABLO与肿瘤[J]. 世界肿瘤杂志, 2011, 0(1): 1-8 |
| |
| 作者姓名： | 曾辉 黄绪群[综述] 伍钢 龙志雄[审校] |
| |
| 作者单位： | [1]武汉市第五医院肿瘤中心,湖北武汉430050 [2]黄石市第一医院肿瘤I科,湖北武汉435000 [3]华中科技大学同济医学院附属协和医院肿瘤中心,湖北武汉430023 |
| |
| 摘 要： | Smac/DIABLO即第2个线粒体衍生的半胱天冬氨酸蛋白酶激活剂/低等电位点的凋亡抑制蛋白的直接结合蛋白,是近年来发现的一种线粒体促凋亡蛋白,它通过消除凋亡抑制蛋白家族的功能而增强半胱天冬氨酸蛋白酶活性,促进细胞的凋亡.本文从Smac/DIABLO的生物学特征、参与凋亡的机制、与肿瘤的关系等方面以及研究中存在的一些问...
|
| 关 键 词： | Smac/DIABLO 肿瘤 凋亡抑制蛋白 天冬氨酸特异性半胱氨酸蛋白酶 |
Mitochondrial protein Smac/DIABLO and the tumor |
| |
| Affiliation: | ZENG Hui, HUANG Xu-qun, WU Gang, LONG Zhi-xiongI (1Cancer Center, Fifth Hospital of Wuhan, Wuhan 430050, China; 2 Department of Oncology, Huangshi City First Hospital, Huangshi 435000, China; 3. Huazhong University of Science and Technology, Union Hospital. Tongji Medical College Cancer Center, Wuhan 430023, China) |
| |
| Abstract: | Smac/DIABLO, the first two mitochondria-derived activator of caspase/low potential point of direct inhibitor of apoptosis protein binding protein, is a recent discovered mitochondria lpro-apoptotic protein. It enhanced caspase activity by eliminating the function of inhibitor of apoptosis protein family, and promoting apoptosis. In this paper, we briefly reviewed biological characteristics, the mechanisms involved in apoptosis, the relations with tumor of Smac/DIABLO, and some of the problems existing in the research and possible research trends. |
| |
| Keywords: | Smac / DIAB LO tumor Inhibitor of apoptosis protein Caspases |
| 本文献已被 维普 等数据库收录！ |
|
