| 肥厚型心肌病病因学研究进展 |
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| 引用本文： | 温华知,江洪. 肥厚型心肌病病因学研究进展[J]. 心血管病学进展, 2006, 27(Z1): 23-26 |
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| 作者姓名： | 温华知 江洪 |
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| 作者单位： | 武汉大学人民医院心内科,湖北,武汉,430060 |
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| 摘 要： | 肥厚型心肌病是以心室壁心肌的非对称性肥厚为特征的一种特发性心肌疾病,目前被认为是一种基因突变所导致的常染色体疾病。在人类,在编码与构成肌小节有关的蛋白质的基因中,现在发现至少有11种基因,超过200种不同的基因突变类型与肥厚型心肌病有关。另外,一些与肌小节无关的基因突变也参与了该病的发生。
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| 关 键 词： | 肥厚型心肌病 基因 基因突变 |
| 文章编号： | 1004-3934(2006)增刊-0023-04 |
| 修稿时间： | 2006-04-02 |
Etiology of Hypertrophic Cardiomyopathy |
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| WEN Hua-zhi,JIANG Hong. Etiology of Hypertrophic Cardiomyopathy[J]. Advances in Cardiovascular Diseases, 2006, 27(Z1): 23-26 |
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| Authors: | WEN Hua-zhi JIANG Hong |
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| Abstract: | Hypertrophic cardiomyopathy is a primary disorder of the myocardium characterised by disproportionate hypertrophy of the ventricular wall.It is the most common genetic cardiac disease,there are at least 11 genes that encode sarcomere proteins,more than 200 types of mutations relate to hypertrophic cardiomyopathy.In addition,a lot of mutations having nothing to do with sarcomere proteins also contribut to this disease. |
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| Keywords: | hypertrophic cardiomyopathy gene gene mutation |
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