奴卡菌病（2例报告及文献复习）

目的：提高对奴卡菌病的早期诊断率。方法：报告２例奴卡菌病并复习文献，对其发病高危因素、临床表现、诊断、治疗及预后进行分析。结果：２例奴卡菌病患者，基础疾病分别为肾病综合征及系统性红斑狼疮，均有长期大量使用肾上腺皮质激素史。２例均经病原菌的分离和鉴定后确诊为奴卡菌病。２例患者均合并有脑脓肿。例１因肾病综合征未使用磺胺治疗，例２因磺胺对肾毒性作用而停用。２例患者均死亡。结论：对可疑患者，提高病原菌的分

Nocardiosis report of 2 cases and literature review

Objective:To attempt in improving the early diagnosis of nocardiosis.Methods:Two cases with nocardiosis confirmed by seperating nocardia asteroides were reported and the allied literatures were reviewed on the high risk factors, clinical features, diagnosis, prognosis and treatment of nocardiosis. Results:The two patients had the basic diseases of nephrotic syndrome (NS) and systemic lupus erythematosus and had used steroids for a long term before admission. And both of them were also complicated with cerebral abscess. The first case did not use sulphadiazine (SD) because of his NS. The second case used the SD, but interrupted as renal poisoning developed. Both cases died. Conclusion:The isolation and determination of nocardia asteroides is the funtamental tool for early diagnosis of nocardiosis. The sulfonamide is the first line drug for treatment, but renal toxicity should be watched carefully. The prognosis will be very bad if accompanied with cerebral absess.