高血压患者脉搏波速度的变化及琥珀酸美托乐尔缓释片干预的影响

目的探讨琥珀酸美托乐尔缓释片对高血压患者脉搏波速度的影响。方法28例首次确诊的高血压患者与28例正常对照组对比分析血压、血糖、血脂和脉搏波速度，琥珀酸美托乐尔缓释片治疗12周后重复测量上述指标，前后对比分析血压和脉搏波速度的变化。结果高血压患者收缩压（156．3±8．6）mmHg比（112．6±11．9mmHg、舒张压（103．6±6．7）mmHg比（68．2±8．9）mmHg和脉搏波速度（1971．3±187．4）cm／s比（1187．2±198．5）cm／s显著高于正常对照组（P〈0．05）。琥珀酸美托乐尔缓释片治疗12周后，患者心率（85．2±4．7）比（64．5±6．3）收缩压（156．3±8．6）mmHg比（121．9±7．9）mmHg、舒张压（103．6±6．7）mmHg比（76．3±5．1）mmHg和脉搏波速度（1971．3±187．4）cm／s比（1236．5±186．3）cm／s）显著下降（P〈0．05）。结论琥珀酸美托乐尔缓释片可以降低高血压患者的脉搏波速度，改善动脉顺应性。

Application of Combined Detection of Lipoprotein (a) and Total Bile Acid in the Diagnosis of Acute Cerebral Infarction

Objective To evaluate the effects of metoprolol succinate sustained-release tablets on Brachial-ankle pulse wave velocity(baPWV) in patients with essential hypertension.Methods The levels of serum blood lipid and blood glucose,blood pressure,heart rate and baPWV were measured respectively in twenty-eight patients with essential hypertension and twenty-eight healthy persons with normal blood pressure.After twelve weeks treated with metoprolol succinate sustained-release tablets,The blood pressure and baPWV were measured again and were studied in patients with essential hypertension.Results The systolic blood pressure (156.3 ±8.6) mm Hg vs (112.6 ± 11.9) mm Hg,diastolic blood pressure (103.6 ± 6.7) mm Hg vs (68.2 ± 8.9) mm Hg and baPWV(1971.3 ± 187.4)cm/s vs(1187.2 ± 198.5)cm/s in patients with essential hypertension were higher than that of healthy persons with normal blood pressure significantly(P ＜ 0.05),The heart rate (85.2 ±4.7) vs (64.5 ± 6.3) beat/min,systolic blood pressure (156.3 ± 8.6) mm Hg vs (121.9 ± 7.9) mm Hg,diastolic blood pressure(103.6 ± 6.7) mm Hg vs (76.3 ± 5.1) mm Hg and baPWV (1971.3 ± 187.4) cm/s vs (1236.5 ± 186.3)cm/s were decreased significantly in patients with essential hypertension(P ＜ 0.05)after treated with metoprolol succinate sustained-release tablets.Conclusion Metoprolol succinate sustained-release tablets treated in patients with essential hypertension can decreased pulse wave velocity,impore elasticity of large arterise and increase the distensibility of aorta.