| C-C亚族趋化因子与糖尿病肾病 |
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| 引用本文： | 吕秀娟,王秋月.C-C亚族趋化因子与糖尿病肾病[J].国外医学：内科学分册,2009,36(4):192-195. |
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| 作者姓名： | 吕秀娟 王秋月 |
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| 作者单位： | 中国医科大学第一附属医院内分泌科,辽宁沈阳,110001
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| 摘 要： | C—C亚族趋化因子大部分由激活的T细胞和单核细胞产生，主要包括单核细胞趋化蛋白（MCP）-1和正常T细胞活化后表达和分泌的调节蛋白（RANTES）。MCP-1和RANTES是单核／巨噬细胞的特异性趋化因子，在糖尿病肾病（DN）肾组织中表达增加。高水平的C—C趋化因子通过与其受体结合介导单核／巨噬细胞在肾组织的募集和分化，导致肾小球系膜细胞增生，细胞外基质积聚及肾小管纤维化。阻止C—C趋化因子表达将有可能为治疗DN开辟一条新的途径。
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| 关 键 词： | C—C亚族趋化因子 C—C亚族趋化因子受体 糖尿病.肾病 |
Cysteine-cysteine chemokine and diabetic nephropathy |
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| LV Xiu-juan,WANG Qiu-yue.Cysteine-cysteine chemokine and diabetic nephropathy[J].Foreign Medical Sciences(Section of Internal Medicine),2009,36(4):192-195. |
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| Authors: | LV Xiu-juan WANG Qiu-yue |
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| Institution: | LV Xiu-juan,WANG Qiu-yue.Department of Endocrinology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China |
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| Abstract: | Cysteine-cysteine chemokine mainly produced by activated T cells and monocytes especially including monocyte chemotactic protein(MCP)-1 and RANTES protein which was expressed and secreted by activated T cells.MCP-1 and RANTES are specific chemokines of monocyte/macrophage,the level of which increases in the kidney of diabetic nephropathy.The high-level of cysteine-cysteine chemokine binding to its receptor and mediating the recruitment and activation of monocyte/macrophage can induce mesangial cell prolifer... |
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| Keywords: | Cysteine-cysteine chemokine Cysteine-cysteine chemokine receptor Diabetic nephropathy |
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